Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
AP Shah, KR Majeti, FK Ekman, S Selvaraj, E Soupene… - bioRxiv, 2024 - biorxiv.org
Blood transfusion plays a vital role in modern medicine. However, availability is contingent
on donated blood, and frequent shortages pose a significant healthcare challenge. Ex vivo …
on donated blood, and frequent shortages pose a significant healthcare challenge. Ex vivo …
Dual α-Globin and Truncated EPO Receptor Knockin Restores Hemoglobin Production in α-Thalassemia-Derived Hematopoietic Stem and Progenitor Cells
SN Chu, E Soupene, B Wienert, H Yin, D Sharma, K Jia… - Blood, 2023 - Elsevier
Introduction: α-thalassemia major (ATM) is an autosomal recessive disorder where all four
copies of the α-globin gene are deleted. A traditionally lethal disease due to severe fetal …
copies of the α-globin gene are deleted. A traditionally lethal disease due to severe fetal …