Sugar-coated killer: serotype 3 pneumococcal disease
JN Luck, H Tettelin, CJ Orihuela - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant
and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents …
and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents …
Producing polished prokaryotic pangenomes with the Panaroo pipeline
Population-level comparisons of prokaryotic genomes must take into account the substantial
differences in gene content resulting from horizontal gene transfer, gene duplication and …
differences in gene content resulting from horizontal gene transfer, gene duplication and …
Pneumococcal surface proteins as virulence factors, immunogens, and conserved vaccine targets
Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths
annually despite the availability of several multivalent pneumococcal conjugate vaccines …
annually despite the availability of several multivalent pneumococcal conjugate vaccines …
Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an …
Background Invasive pneumococcal disease remains an important health priority owing to
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
A bacterial pan-genome makes gene essentiality strain-dependent and evolvable
Many bacterial species are represented by a pan-genome, whose genetic repertoire far
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …
Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
Effect of pneumococcal conjugate vaccines and SARS-CoV-2 on antimicrobial resistance and the emergence of Streptococcus pneumoniae serotypes with reduced …
J Sempere, M Llamosí, BL Ruiz, I Del Rio… - The Lancet …, 2022 - thelancet.com
Background Epidemiological studies are necessary to explore the effect of current
pneumococcal conjugate vaccines (PCVs) against antibiotic resistance, including the rise of …
pneumococcal conjugate vaccines (PCVs) against antibiotic resistance, including the rise of …
The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi
Streptococcus pneumoniae causes substantial mortality among children under 5-years-old
worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing …
worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing …
Improved prediction of bacterial genotype-phenotype associations using interpretable pangenome-spanning regressions
Discovery of genetic variants underlying bacterial phenotypes and the prediction of
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …
Proton motive force disruptors block bacterial competence and horizontal gene transfer
Streptococcus pneumoniae is a commensal of the human nasopharynx that can also cause
severe antibiotic-resistant infections. Antibiotics drive the spread of resistance by inducing S …
severe antibiotic-resistant infections. Antibiotics drive the spread of resistance by inducing S …