[HTML][HTML] Sugar-coated killer: serotype 3 pneumococcal disease
JN Luck, H Tettelin, CJ Orihuela - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant
and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents …
and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents …
[HTML][HTML] Producing polished prokaryotic pangenomes with the Panaroo pipeline
Population-level comparisons of prokaryotic genomes must take into account the substantial
differences in gene content resulting from horizontal gene transfer, gene duplication and …
differences in gene content resulting from horizontal gene transfer, gene duplication and …
[HTML][HTML] Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era …
Background Invasive pneumococcal disease remains an important health priority owing to
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
[HTML][HTML] A bacterial pan-genome makes gene essentiality strain-dependent and evolvable
Many bacterial species are represented by a pan-genome, whose genetic repertoire far
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …
[HTML][HTML] Global genomic epidemiology of Streptococcus pyogenes
Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide
causing a range of clinical manifestations in humans. Colonizing a range of ecological …
causing a range of clinical manifestations in humans. Colonizing a range of ecological …
[HTML][HTML] Effect of pneumococcal conjugate vaccines and SARS-CoV-2 on antimicrobial resistance and the emergence of Streptococcus pneumoniae serotypes with …
J Sempere, M Llamosí, BL Ruiz, I Del Río… - The Lancet …, 2022 - thelancet.com
Background Epidemiological studies are necessary to explore the effect of current
pneumococcal conjugate vaccines (PCVs) against antibiotic resistance, including the rise of …
pneumococcal conjugate vaccines (PCVs) against antibiotic resistance, including the rise of …
[HTML][HTML] Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
Improved prediction of bacterial genotype-phenotype associations using interpretable pangenome-spanning regressions
Discovery of genetic variants underlying bacterial phenotypes and the prediction of
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …
[HTML][HTML] Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole …
Background Serotype 24F is one of the emerging pneumococcal serotypes after the
introduction of pneumococcal conjugate vaccine (PCV). We aimed to identify lineages …
introduction of pneumococcal conjugate vaccine (PCV). We aimed to identify lineages …
[PDF][PDF] Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model
Streptococcus pneumoniae is the primary cause of community-acquired bacterial
pneumonia with rates of penicillin and multidrug-resistance exceeding 80% and 40 …
pneumonia with rates of penicillin and multidrug-resistance exceeding 80% and 40 …