The 'EF-hand'Ca2+-binding motif plays an essential role in eukaryotic cellular signalling,
and the proteins containing this motif constitute a large and functionally diverse family. The …

Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-
covalently bind to ubiquitin. These recently discovered motifs interpret and transmit …

Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia
protein (CALM), are closely related proteins that play important roles in clathrin-mediated …

To generate structures consistent with both the local and nonlocal interactions responsible
for protein stability, 3 and 9 residue fragments of known structures with local sequences …

Cargo molecules have to be included in carrier vesicles of different forms and sizes to be
transported between organelles. During this process, a limited set of proteins, including the …

▪ Abstract There has recently been considerable progress in understanding the regulation of
clathrin-coated vesicle (CCV) formation and function. These advances are due to the …

Endocytosis is crucial for an array of cellular functions and can occur through several distinct
mechanisms with the capacity to internalize anything from small molecules to entire cells …

The clathrin assembly lymphoid myeloid leukemia (CALM) gene encodes a putative
homologue of the clathrin assembly synaptic protein AP180. Hence the biochemical …

Regulation of endocytic transport is controlled by an elaborate network of proteins. Rab GTP-
binding proteins and their effectors have well-defined roles in mediating specific endocytic …

The ability to actively remodel membranes in response to nucleotide hydrolysis has largely
been attributed to GTPases of the dynamin superfamily, and these have been extensively …