To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic
stability and cancer development. Imbalanced dNTP pools can lead to enhanced …

Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …

Abstract Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine
protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin …

SAMHD1 is a triphosphohydrolase enzyme that controls the intracellular level of
deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune sensing and …

Cells of the myeloid lineage, particularly macrophages, serve as primary hosts for HIV in
vivo, along with CD4 T lymphocytes. Macrophages are present in virtually every tissue of the …

Human immunodeficiency virus type 1 (HIV-1) establishes latency in resting memory CD4+
T cells and cells of myeloid lineage. In contrast to the T cells, cells of myeloid lineage are …

The ubiquitin-proteasome system (UPS) ensures regulation of the protein pool in the cell by
ubiquitination of proteins followed by their degradation by the proteasome. It plays a central …

Human Immunodeficiency Virus (HIV) infects cells from the immune system and has thus
developed tools to circumvent the host immunity and use it in its advance. Dendritic cells …

SAMHD 1 possesses multiple functions, but whether cellular factors regulate SAMHD 1
expression or its function remains not well characterized. Here, by investigating why cultured …