Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease

SP Yu, MQ Jiang, SS Shim, S Pourkhodadad… - Molecular …, 2023 - Springer
Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

The role of NMDA receptors in Alzheimer's disease

J Liu, L Chang, Y Song, H Li, Y Wu - Frontiers in neuroscience, 2019 - frontiersin.org
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Structure, function, and allosteric modulation of NMDA receptors

KB Hansen, F Yi, RE Perszyk, H Furukawa… - Journal of General …, 2018 - rupress.org
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

Influence of glutamate and GABA transport on brain excitatory/inhibitory balance

SMS Sears, SJ Hewett - Experimental Biology and Medicine, 2021 - journals.sagepub.com
An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

P Paoletti, C Bellone, Q Zhou - Nature Reviews Neuroscience, 2013 - nature.com
NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

[HTML][HTML] Molecular mechanisms of ischemia and glutamate excitotoxicity

D Neves, IL Salazar, RD Almeida, RM Silva - Life sciences, 2023 - Elsevier
Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Interface engineering of highly efficient perovskite solar cells

H Zhou, Q Chen, G Li, S Luo, T Song, HS Duan… - Science, 2014 - science.org
Advancing perovskite solar cell technologies toward their theoretical power conversion
efficiency (PCE) requires delicate control over the carrier dynamics throughout the entire …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

NMDA receptor functions in health and disease: Old actor, new dimensions

JP Dupuis, O Nicole, L Groc - Neuron, 2023 - cell.com
N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

MF Bastide, WG Meissner, B Picconi, S Fasano… - Progress in …, 2015 - Elsevier
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …