Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …

Abstract Learning Objectives After completing this course, the reader should be able to:
Understand the advantages and disadvantages of recombinant adenoviral vectors for gene …

Adenoviruses are attractive vectors for the delivery of foreign genes into mammalian cells for
gene therapy. However, current vectors retain many viral genes that, when expressed at low …

The intestinal epithelium serves as a dynamic barrier which, in the course of its normal
function, maintains regulated uptake of nutrients and water at the same time as excluding …

For the study of hepatitis B virus infection, no permissive cell line or small animal is
available. Stably transfected cell lines and transgenic mice which contain hepadnavirus …

Adenoviruses (Ads) are intermediate-sized mammalian DNA viruses with a double-stranded
linear genome of 36 kb. The icosohedral virion has been shown to accommodate up to …

Idiopathic Pulmonary Fibrosis (IPF) is a chronic interstitial lung disease which results in end-
stage fibrosis. The pathogenesis is believed to be related to a dysregulation in cross-talk …

BACKGROUND & AIMS:: Peroxisome proliferator-activated receptor γ (PPARγ) is one of the
nuclear receptors that plays a central role in adipocyte differentiation and insulin sensitivity …

Mice bearing breast tumors were treated with a single dose of an adenovirus expressing
interleukin-12 (AdmlL-12.1) injected intratumorally, which produced regressions in greater …

Adenoviral (Ad) vectors can efficiently transduce a broad range of cell types and have been
used extensively in preclinical and clinical studies for gene delivery applications. The …