Immune checkpoint blockade (ICB) therapies have achieved remarkable clinical responses
in patients with many different types of cancer; however, most patients who receive ICB …

Oncolytic viruses (OVs) as one promising antitumor methods have made important
contributions to tumor immunotherapy, which arouse increasing attention. They provide the …

Immune checkpoint molecules are promising anticancer targets, among which therapeutic
antibodies targeting the PD-1/PD-L1 pathway have been widely applied to cancer treatment …

Helicobacter pylori neutrophil-activating protein (HP-NAP), a major virulence factor of H.
pylori, plays a role in bacterial protection and host inflammation. HP-NAP activates a variety …

Measles virus (MV) vaccine strains have shown significant preclinical antitumor activity
against glioblastoma (GBM), the most lethal glioma histology. In this first in human trial …

Cancer Immunotherapy relies on harnessing a patient's immune system to fine-tune specific
anti-tumor responses and ultimately eradicate cancer. Among diverse therapeutic …

Glioblastoma (GBM) is the most common primary malignant tumor in the brain, accounting
for 51.4% of all primary brain tumors. GBM has a highly immunosuppressive tumor …

Despite recent therapeutic advances, metastatic breast cancer (MBC) remains incurable.
Engineered measles virus (MV) constructs based on the attenuated MV Edmonston vaccine …

Tumor-associated macrophages (TAMs) can directly clear tumor cells and enhance the
phagocytic ability of immune cells. An abundance of TAMs at the site of the glioblastoma …

Oncolytic viruses (OVs) have been gaining attention in the pharmaceutical industry as a
novel immunotherapeutic and therapeutic adjuvant due to their ability to induce and boost …