The emergence of the SARS‐CoV‐2 strain of the human coronavirus has thrown the world
into the midst of a new pandemic. In the human body, the virus causes COVID‐19, a disease …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Abstract Treatment-refractory lupus nephritis (LN) has a high risk of a poor outcome and is
often life-threatening. Here we report a case series of six patients (one male and five …

Anifrolumab (anifrolumab-fnia; Saphnelo™) is a monoclonal antibody antagonist of the type
1 interferon receptor (IFNAR). It is being developed by AstraZeneca (under license from …

Objectives To investigate associations between a high genetic disease risk and disease
severity in patients with systemic lupus erythematosus (SLE). Methods Patients with SLE (n …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can give rise to
different clinical manifestations that are directly related to viral tissue damage or indirectly …

Introduction Despite available therapies, persistently active and corticosteroid-dependent
Systemic Lupus Erythematosus (SLE) represent a significant therapeutic challenge. The …

Systemic lupus erythematosus (SLE) is a multisystem, chronic autoimmune disease where
treatment varies by patient and disease activity. Strong preclinical results and clinical …

Abstract Objectives Systemic Lupus Erythematosus is a complex autoimmune disease that
leads to significant worsening of quality of life and mortality. Flares appear unpredictably …