Radiomics: the bridge between medical imaging and personalized medicine

P Lambin, RTH Leijenaar, TM Deist… - Nature reviews Clinical …, 2017 - nature.com
Radiomics, the high-throughput mining of quantitative image features from standard-of-care
medical imaging that enables data to be extracted and applied within clinical-decision …

Predicting outcomes in radiation oncology—multifactorial decision support systems

P Lambin, RGPM Van Stiphout… - Nature reviews Clinical …, 2013 - nature.com
With the emergence of individualized medicine and the increasing amount and complexity of
available medical data, a growing need exists for the development of clinical decision …

Exploring the role of cancer stem cells in radioresistance

M Baumann, M Krause, R Hill - Nature Reviews Cancer, 2008 - nature.com
Radiobiological research over the past decades has provided evidence that cancer stem
cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours …

The concurrent chemoradiation paradigm—general principles

TY Seiwert, JK Salama, EE Vokes - Nature clinical practice Oncology, 2007 - nature.com
During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent
chemoradiotherapy has improved cancer care dramatically. Significant contributions have …

A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiation

SA Eschrich, J Pramana, H Zhang, H Zhao… - International Journal of …, 2009 - Elsevier
PURPOSE: Development of a radiosensitivity predictive assay is a central goal of radiation
oncology. We reasoned a gene expression model could be developed to predict intrinsic …

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

L Cui, S Her, GR Borst, RG Bristow, DA Jaffray… - Radiotherapy and …, 2017 - Elsevier
The utilization of gold nanoparticles (AuNPs) as radiosensitizers has shown great promise in
pre-clinical research. In the current review, the physical, chemical, and biological pathways …

Decision support systems for personalized and participative radiation oncology

P Lambin, J Zindler, BGL Vanneste… - Advanced drug delivery …, 2017 - Elsevier
A paradigm shift from current population based medicine to personalized and participative
medicine is underway. This transition is being supported by the development of clinical …

Prediction of radiation sensitivity using a gene expression classifier

JF Torres-Roca, S Eschrich, H Zhao, G Bloom, J Sung… - Cancer research, 2005 - AACR
The development of a successful radiation sensitivity predictive assay has been a major
goal of radiation biology for several decades. We have developed a radiation classifier that …

[HTML][HTML] Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase

R Carruthers, SU Ahmed, K Strathdee… - Molecular …, 2015 - Elsevier
Resistance to radiotherapy in glioblastoma (GBM) is an important clinical problem and
several authors have attributed this to a subpopulation of GBM cancer stem cells (CSCs) …

Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation

JS Hall, J Taylor, HR Valentine, JJ Irlam… - British journal of …, 2012 - nature.com
Background: As degradation of formalin-fixed paraffin-embedded (FFPE) samples limits the
ability to profile mRNA expression, we explored factors predicting the success of mRNA …