Besides pathology: long non-coding RNA in cell and tissue homeostasis

A Salviano-Silva, SC Lobo-Alves, RC Almeida… - Non-coding RNA, 2018 - mdpi.com
A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …

gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration

J Orvis, B Gottfried, J Kancherla, RS Adkins, Y Song… - Nature …, 2021 - nature.com
To the Editor—Biologists are important stakeholders in genomic data, both as data
generators and as users of genomic data resources. Tools to efficiently visualize and …

High-throughput mapping of long-range neuronal projection using in situ sequencing

X Chen, YC Sun, H Zhan, JM Kebschull, S Fischer… - Cell, 2019 - cell.com
Understanding neural circuits requires deciphering interactions among myriad cell types
defined by spatial organization, connectivity, gene expression, and other properties …

Understanding the role of lncRNAs in nervous system development

BS Clark, S Blackshaw - Long Non Coding RNA Biology, 2017 - Springer
The diversity of lncRNAs has expanded within mammals in tandem with the evolution of
increased brain complexity, suggesting that lncRNAs play an integral role in this process. In …

[HTML][HTML] Knockdown of lncRNA PVT1 inhibits glioma progression by regulating miR-424 expression

Y Han, X Li, F He, J Yan, C Ma, X Zheng… - Oncology …, 2019 - ncbi.nlm.nih.gov
Abstract Plasmacytoma variability translocation 1 (PVT1), an oncogene, has been reported
to be highly expressed in many tumors, including human glioma, gastric cancer, and non …

[HTML][HTML] The use of nonhuman primates in studies of noise injury and treatment

JA Burton, MD Valero, TA Hackett… - The Journal of the …, 2019 - pubs.aip.org
Exposure to prolonged or high intensity noise increases the risk for permanent hearing
impairment. Over several decades, researchers characterized the nature of harmful noise …

[HTML][HTML] Porcine endemic diarrhea virus infection regulates long noncoding RNA expression

J Chen, C Zhang, N Zhang, G Liu - Virology, 2019 - Elsevier
Long noncoding RNAs (lncRNAs) have been implicated in various life processes. However,
the lncRNA expression and potential functions in porcine endemic diarrhea virus (PEDV) …

Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function

LA Dunbar, P Patni, C Aguilar, P Mburu… - EMBO Molecular …, 2019 - embopress.org
Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia
bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms …

Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior

PB Chen, R Chen, N LaPierre, Z Chen, J Mefford… - Cell Genomics, 2024 - cell.com
Knowing the genes involved in quantitative traits provides an entry point to understanding
the biological bases of behavior, but there are very few examples where the pathway from …

Non-coding RNA regulators of diabetic polyneuropathy

C Meydan, N Üçeyler, H Soreq - Neuroscience Letters, 2020 - Elsevier
Diabetic polyneuropathy is a common and disturbing complication of diabetes mellitus,
presenting patients and caregivers with a substantial disease burden. Emerging …