Understanding the genetic architecture of speciation is a major goal in evolutionary biology.
Hybrid dysfunction is thought to arise most commonly through negative interactions between …

Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

Interactions between alleles and across environments play an important role in the fitness of
hybrids and are at the heart of the speciation process. Fitness landscapes capture these …

All genes interact with other genes, and their additive effects and epistatic interactions affect
an organism's phenotype and fitness. Recent theoretical and empirical work has advanced …

Developmental system drift is a likely mechanism for the origin of hybrid incompatibilities
between closely related species. We examine here the detailed mechanistic basis of hybrid …

The snowball hypothesis suggests that the number of genetic incompatibilities between two
populations will accumulate faster than linearly as they diverge... Genetic incompatibilities …

Mutations to gene regulatory networks can be maladaptive or a source of evolutionary
novelty. Epistasis confounds our understanding of how mutations affect the expression …

Dobzhansky and Muller proposed a general mechanism through which microevolution, the
substitution of alleles within populations, can cause the evolution of reproductive isolation …

In biological processes involving gene networks, genes regulate other genes that determine
the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a …

We build on previous observations that Hill–Robertson interference generates an advantage
of sex that, in structured populations, can be large enough to explain the evolutionary …