The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …

The embryo instructs the allocation of cell states to spatially regulate functions. In the
blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and …

Trophoblasts are specialized epithelial cells that perform critical functions during blastocyst
implantation and mediate maternal–fetal communication during pregnancy. However, our …

Trophoblast stem (TS) cells were first isolated from the mouse placenta; however, little is
known about their maintenance and niche in vivo. TS cells, like other stem cells, have a …

MicroRNAs (miRNAs) represent small noncoding RNAs that are involved in physiological
and developmental processes by posttranscriptionally inhibiting gene expression. One of …

In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained
prominence as a compelling research objective, illuminating the establishment of the …

In mammalian species, endometrial receptivity is driven by maternal factors independently of
embryo signals. When pregnancy initiates, paracrine secretions of the preattachment …

Simple Summary In this study, we investigated the critical process of cell fate determination
in mouse embryos, focusing on the transition from embryonic stem cells (ESC) to trophoblast …

Although phenotypic abnormalities frequently appear in the placenta following somatic cell
nuclear transfer (SCNT), mouse trophoblast stem cells (TSCs) established from SCNT …

Trophoblast stem cells (TSCs) are a heterogeneous cell population despite the presence of
fibroblast growth factor (FGF) and transforming growth factor β (TGFB) as key growth factors …