The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

Rheumatoid arthritis (RA) is an inflammatory disease typically affecting the joints, but the
systemic inflammatory process may involve other tissues and organs. Many extra-articular …

Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous, unpredictable and ultimately
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …

Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

Fibrosis can develop in most organs and causes organ failure. The most common type of
lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung …

Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …