Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …

Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …

Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Previous research has established leader development as an ongoing process across the
entire lifespan. Experience, especially on-the-job experience, has been increasingly …

It has been 70 years since Donald Hebb published his formalized theory of synaptic
adaptation during learning. Hebb's seminal work foreshadowed some of the great …

Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …

Background The association between developmental adversity and children's functioning is
complex, particularly given the multifaceted nature of adverse experiences. The association …

Psychiatric diseases have a strong heritable component known to not be restricted to DNA
sequence-based genetic inheritance alone but to also involve epigenetic factors in germ …

Abstract Long Interspersed Nuclear Elements-1s (L1s) are transposable elements that
constitute most of the genome's transcriptional output yet have still largely unknown …