One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

Neglected tropical diseases (NTDs) constitute a group of infectious diseases prevalent in
countries with tropical and subtropical climate that affect the poorest individuals and produce …

The cubane phenyl ring bioisostere paradigm was further explored in an extensive study
covering a wide range of pharmaceutical and agrochemical templates, which included …

Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of
Chagas disease, but long treatment periods at high dosages cause several adverse effects …

Benznidazole (BNZ) serves as the primary drug for treating Chagas Disease and is listed in
the WHO Model List of Essential Medicines for Children. Herein, a new child-friendly oral …

Benznidazole (BZ) tablets are a unique form of treatment available for treating Chagas
disease. Development of a liquid formulation containing BZ easy to administer orally for the …

Nanoemulsions have received a growing attention as colloidal drug carriers for
pharmaceutical applications. Their advantages over conventional formulations include drug …

Benznidazole (BZL) is the drug of choice for the treatment of Chagas' disease, a neglected
parasitic infection. It is poorly soluble in water, which may have a direct impact into its …

Benznidazole, the primary drug used in Chagas' disease treatment, has known side effects,
which may limit its widespread use. Its low solubility could negatively interfere in the …

This work aims to develop novel benznidazole (BZN) solid dispersions (SD) to improve its
solubility and bioavailability properties. Low-substituted hydroxypropylcellulose (L-HPC) …