Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) mainly relay the
information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue
architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

Abstract Development of a multicellular organism from a fertilized egg depends on a precise
balance between symmetric cell divisions to expand the pool of similar cells, and …

Asymmetric cell division is fundamental for generating diversity in multicellular organisms.
The mechanisms that govern asymmetric cell division are increasingly well understood …

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …

Correct spindle positioning is fundamental for proper cell division during development and
in stem cell lineages. Dynein and an evolutionarily conserved ternary complex (nuclear …