In 2011, a novel form of genome instability was reported by Stephens et al., characterized by
tens to hundreds of locally clustered rearrangements affecting one or a few chromosome (s) …

In recent years, the paradigm that genomic abnormalities in cancer cells arise through
progressive accumulation of mutational events has been challenged by the discovery of …

PURPOSE In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively
activated through activating point mutations or genomic amplification. We studied ALK …

Purpose: The tumor genomic copy number profile is of prognostic significance in
neuroblastoma patients. We have studied the genomic copy number profile of cell-free DNA …

Abstract Adult Schwann cells (SCs) possess an inherent plastic potential. This plasticity
allows SCs to acquire repair-specific functions essential for peripheral nerve regeneration …

Background Increased tissue stiffness is a common feature of malignant solid tumors, often
associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix …

Background Vitronectin is a multifunctional glycoprotein known in several human tumors for
its adhesive role in processes such as cell growth, angiogenesis and metastasis. In this …

Microarray data is subject to noise and systematic variation that negatively affects the
resolution of copy number analysis. We describe Rawcopy, an R package for processing of …

Cell therapy using induced pluripotent stem cell (iPSC) derivatives may result in abnormal
tissue generation because the cells undergo numerous cycles of mitosis before clinical …

Background In neuroblastoma (NB), the most powerful prognostic marker, the MYCN
amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), ie coexistence of …