Cell adhesion at the tight junctions: new aspects and new functions

N Wibbe, K Ebnet - Cells, 2023 - mdpi.com
Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-
forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a …

Deciphering internal and external factors influencing intestinal junctional complexes

Z Markovich, A Abreu, Y Sheng, SM Han, R Xiao - Gut Microbes, 2024 - Taylor & Francis
The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the
intricate exchange between internal and external environments. Anchored by evolutionarily …

Cellular segregation in cocultures is driven by differential adhesion and contractility on distinct timescales

M Skamrahl, J Schünemann… - Proceedings of the …, 2023 - National Acad Sciences
Cellular sorting and pattern formation are crucial for many biological processes such as
development, tissue regeneration, and cancer progression. Prominent physical driving …

Light‐Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions

F Cui, S Shen, X Ma, D Fan - Advanced Science, 2024 - Wiley Online Library
Dislocation of anti‐adhesion materials, non‐specific tissue adhesion, and the induction of
secondary fibrinolysis disorders are the main challenges faced by postoperative anti …

[HTML][HTML] Grifola frondosa polysaccharide's therapeutic potential in oxazolone-induced ulcerative colitis

X Liu, M Zhang, S Chen, H Liu, H Ma, T Hu, P Luo… - Carbohydrate …, 2024 - Elsevier
Grifola frondosa polysaccharide (GFP) is a consumable fungus recognized for its potential
health advantages. The present study aimed to investigate the development and potential …

ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1-and TBK1-Regulated Signalling Network

AJ Haas, M Karakus, C Zihni, MS Balda, K Matter - Cells, 2024 - mdpi.com
Tight junctions are a barrier-forming cell–cell adhesion complex and have been proposed to
regulate cell proliferation. However, the underlying mechanisms are not well understood …

Glycyrol Relieves Ulcerative Colitis by Promoting the Fusion of ZO-1 with the Cell Membrane through the Enteric Glial Cells GDNF/RET Pathway

S Lu, Y Xu, H Zhang, Z Liu, J Xu, B Zheng… - Journal of Agricultural …, 2024 - ACS Publications
The damage to the mechanical barrier of the intestinal mucosa is the initiating factor and the
core link of the progression of ulcerative colitis (UC). Protecting the mechanical barrier of the …

PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells

AC Groh, A Möller-Kerutt, K Gilhaus… - Journal of Cell …, 2024 - journals.biologists.com
The evolutionarily conserved apical Crumbs (CRB) complex, consisting of the core
components CRB3a (an isoform of CRB3), PALS1 and PATJ, plays a key role in epithelial …

The epithelium takes the stage in asthma and inflammatory bowel diseases

R López-Posadas, DC Bagley… - Frontiers in Cell and …, 2024 - frontiersin.org
The epithelium is a dynamic barrier and the damage to this epithelial layer governs a variety
of complex mechanisms involving not only epithelial cells but all resident tissue constituents …

PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous …

Q Wei, L Chen, W Luo, C Chen, Y Shi, J Xie… - European Journal of …, 2024 - Elsevier
Oral submucous fibrosis (OSF) is a chronic oral mucosal disease. The pathological changes
of OSF include epithelial damage and subepithelial matrix fibrosis. This study aimed to …