[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer

B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Endoplasmic reticulum stress in liver diseases

A Ajoolabady, N Kaplowitz, C Lebeaupin, G Kroemer… - Hepatology, 2023 - journals.lww.com
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes …

Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis

Q Ding, F Cao, S Lai, H Zhuge, K Chang… - Food Research …, 2022 - Elsevier
This present study was designed to test the protective role of two Lactobacillus plantarum
strains, E680 and ZY08, against alcoholic liver disease (ALD) in C57BL/6 mice. The ALD …

The role of pyroptosis in hepatocellular carcinoma

Z Zou, M Zhao, Y Yang, Y Xie, Z Li, L Zhou, R Shang… - Cellular Oncology, 2023 - Springer
Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for
the majority of all diagnoses and deaths due to liver cancer. The induction of tumor cell …

Autophagy, oxidative stress, and alcoholic liver disease: a systematic review and potential clinical applications

D Salete-Granado, C Carbonell, D Puertas-Miranda… - Antioxidants, 2023 - mdpi.com
Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS)
through its metabolites. This process leads to steatosis and liver inflammation, which are …

Links between autophagy and lipid droplet dynamics

C Xu, J Fan - Journal of Experimental Botany, 2022 - academic.oup.com
Autophagy is a catabolic process in which cytoplasmic components are delivered to
vacuoles or lysosomes for degradation and nutrient recycling. Autophagy-mediated …

Unfolded protein response signaling in liver disorders: a 2023 updated review

S Shreya, CF Grosset, BP Jain - International Journal of Molecular …, 2023 - mdpi.com
Endoplasmic reticulum (ER) is the site for synthesis and folding of secreted and
transmembrane proteins. Disturbance in the functioning of ER leads to the accumulation of …

Endoplasmic reticulum stress in the pathogenesis of alcoholic liver disease

M Na, X Yang, Y Deng, Z Yin, M Li - PeerJ, 2023 - peerj.com
The endoplasmic reticulum (ER) plays a pivotal role in protein synthesis, folding, and
modification. Under stress conditions such as oxidative stress and inflammation, the ER can …

Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress

H Cui, Y Wang, T Zhou, L Qu, X Zhang, Y Wang, M Han… - Oncogene, 2024 - nature.com
Impaired macroautophagy/autophagy flux has been implicated in the treatment of prostate
cancer (PCa). However, the mechanism underlying autophagy dysregulation in PCa …

Activation of mTORC1 by free fatty acids suppresses LAMP2 and autophagy function via ER stress in alcohol-related liver disease

W Guo, W Zhong, L Hao, X Sun, Z Zhou - Cells, 2021 - mdpi.com
Alcohol-related liver disease (ALD) is characterized by accumulation of hepatic free fatty
acids (FFAs) and liver injury. The present study aimed to investigate if mechanistic target of …