Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

▪ Abstract Despite considerable evidence that neuronal activity influences the organization
and function of circuits in the developing and adult brain, the molecular signals that translate …

A sensitive immunohistochemical technique was used, along with highly specific affinity-
purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

The role of neurotrophins as target-derived proteins that promote neuron survival following
their retrograde transport from the terminals to the cell bodies of neurons has been firmly …

The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …

The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells
has been the subject of numerous studies. Administration of exogenous neurotrophic factors …

The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-
derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) …