Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated.
Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy …

Due to their fundamental role in energy production, mitochondria have been traditionally
known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of …

Partitioning of ATP generation between glycolysis and oxidative phosphorylation is central
to cellular bioenergetics but cumbersome to measure. We describe here how rates of ATP …

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …

Breakthrough technologies to measure cellular oxygen consumption and proton efflux are
reigniting the study of cellular energetics by increasing the scope and pace with which …

Background The rate at which cells acidify the extracellular medium is frequently used to
report glycolytic rate, with the implicit assumption that conversion of uncharged glucose or …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

Small, rapidly dividing pluripotent stem cells (PSCs) have unique energetic and biosynthetic
demands compared with typically larger, quiescent differentiated cells. Shifts between …

Focus on the Warburg effect, initially descriptive of increased glycolysis in cancer cells, has
served to illuminate mitochondrial function in many other pathologies. This review explores …

Previously, we showed that high-energy metabolites (lactate and ketones)“fuel” tumor
growth and experimental metastasis in an in vivo xenograft model, most likely by driving …