The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …

Inflammation is a cellular response to factors that challenge the homeostasis of cells and
tissues. Cell-associated and soluble pattern-recognition receptors, eg Toll-like receptors …

Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …

Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …

Geographic atrophy is a blinding form of age-related macular degeneration characterized by
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …

Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Age-related macular degeneration (AMD) is an eye disease underlined by the degradation
of retinal pigment epithelium (RPE) cells, photoreceptors, and choriocapillares, but the exact …

Retrotransposons are mutagenic units able to move within the genome. Despite many
defenses deployed by the host to suppress potentially harmful activities of retrotransposons …

Inflammasomes, key molecular regulators that play an important role in inflammation, consist
of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 …

Purpose.: Lipofuscin (LF) and melanolipofuscin (MLF) of the retinal pigment epithelium
(RPE) are the principal sources of autofluorescence (AF) signals in clinical fundus–AF …