Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …

Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …

Glioblastoma (GBM) is the most lethal type of primary brain cancer. Standard care using
chemo-and radio-therapy modestly increases the overall survival of patients; however …

Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity.
However, the molecular mechanisms underlying the origin of different GBM cell populations …

Purpose To determine the efficacy and toxicity of re-irradiation for patients with recurrent
GBM. Materials and methods We searched various biomedical databases from 1998 to …

Brain delivery of drugs by nanoparticles is a promising strategy that could open up new
possibilities for the chemotherapy of brain tumors. As demonstrated in previous studies, the …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly
universally fatal. Targeted therapy and immunotherapy have had limited success in GBM …

GammaTile is a Food and Drug Administration (FDA)-licensed device consisting of four
cesium-131 (Cs-131) radiation-emitting seeds in the collagen tile about the postage stamp …

The Response Assessment in Neuro-Oncology criteria were developed as an objective tool
for radiologic assessment of treatment response in high-grade gliomas. Imaging plays a …

Background Topotecan is cytotoxic to glioma cells but is clinically ineffective because of
drug delivery limitations. Systemic delivery is limited by toxicity and insufficient brain …