How protons pave the way to aggressive cancers

P Swietach, E Boedtkjer, SF Pedersen - Nature Reviews Cancer, 2023 - nature.com
Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

[HTML][HTML] Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

B Chen, P Yu, WN Chan, F Xie, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Lactate activates the mitochondrial electron transport chain independently of its metabolism

X Cai, CP Ng, O Jones, TS Fung, KW Ryu, D Li… - Molecular cell, 2023 - cell.com
Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

The bidirectional relationship between metabolism and cell cycle control

FF Diehl, KM Sapp, MG Vander Heiden - Trends in Cell Biology, 2024 - cell.com
The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Lactate modulates iron metabolism by binding soluble adenylyl cyclase

W Liu, S Zhang, Q Li, Y Wu, X Jia, W Feng, Z Li, Y Shi… - Cell Metabolism, 2023 - cell.com
Overproduction of lactate (LA) can occur during exercise and in many diseases such as
cancers. Individuals with hyperlactatemia often display anemia, decreased serum iron, and …

SUMO proteases: from cellular functions to disease

LA Claessens, ACO Vertegaal - Trends in Cell Biology, 2024 - cell.com
Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in
regulating diverse cellular processes including gene expression, cell cycle progression …

Cardinal features of immune memory in innate lymphocytes

EK Santosa, JC Sun - Nature immunology, 2023 - nature.com
The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

C Zhou, Y Zou, R Xu, X Han, Z Xiang, H Guo, X Li… - Materials …, 2023 - pubs.rsc.org
Living probiotics secrete bioactive substances to accelerate wound healing, but the clinical
application of antibiotics inhibits the survival of probiotics. Inspired by the chelation of tannic …

Mitochondrial fragmentation promotes inflammation resolution responses in macrophages via histone lactylation

LI Susser, MA Nguyen, M Geoffrion… - … and Cellular Biology, 2023 - Taylor & Francis
During the inflammatory response, macrophage phenotypes can be broadly classified as
pro-inflammatory/classically activated “M1”, or pro-resolving/alternatively “M2” …

[HTML][HTML] The role of lactate in cardiovascular diseases

J Ouyang, H Wang, J Huang - Cell Communication and Signaling, 2023 - Springer
Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases
include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and …