Reactive oxygen species are ubiquitous signaling molecules in biological systems. Four
members of the NADPH oxidase (Nox) enzyme family are important sources of reactive …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Despite its toxicity, H 2 O 2 is produced as a signaling molecule that oxidizes critical cysteine
residues of effectors such as protein tyrosine phosphatases in response to activation of cell …

Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or
hydroxyl radical, play an important role in inflammation processes as well as in transduction …

Reactive oxygen species (ROS) are generated in response to growth factors, cytokines, G
protein–coupled receptor agonists, or shear stress, and function as signaling molecules in …

Significance: Hepatic fibrosis is the common pathophysiologic process resulting from
chronic liver injury, characterized by the accumulation of an excessive extracellular matrix …

Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including
ischemia–reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and …

Generation of reactive oxygen species (ROS) by plasma membrane–localized NADPH
oxidase (Nox 2) is a major mechanism of cell signaling associated with activation of the …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or
NOX) plays a critical role in the inflammatory response and fibrosis in several organs such …