Pharmacotherapy of obesity: available medications and drugs under investigation

E Pilitsi, OM Farr, SA Polyzos, N Perakakis… - Metabolism, 2019 - Elsevier
Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …

Molecular physiology of membrane guanylyl cyclase receptors

M Kuhn - Physiological reviews, 2016 - journals.physiology.org
Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

BCAA metabolism and insulin sensitivity–Dysregulated by metabolic status?

NP Gannon, JK Schnuck… - Molecular nutrition & food …, 2018 - Wiley Online Library
Branched‐chain amino acids (BCAAs) appear to influence several synthetic and catabolic
cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most …

An update regarding the bioactive compound of cereal by-products: Health benefits and potential applications

AC Fărcaș, SA Socaci, SA Nemeș, OL Pop, TE Coldea… - Nutrients, 2022 - mdpi.com
Cereal processing generates around 12.9% of all food waste globally. Wheat bran, wheat
germ, rice bran, rice germ, corn germ, corn bran, barley bran, and brewery spent grain are …

Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications

W Jiang, K Ding, R Yue, M Lei - Critical reviews in food science …, 2024 - Taylor & Francis
Diabetes mellitus (DM) is a global health issue in the twenty-first century, and there are
numerous challenges in preventing and alleviating its chronic complications. The herb …

[HTML][HTML] Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK

D Rogacka, I Audzeyenka, M Rychłowski… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Podocyte insulin sensitivity is critical for glomerular function, and the loss of appropriate
insulin signaling leads to alterations and disorders featuring diabetic nephropathy. Energy …

Different proportions of branched-chain amino acids modulate lipid metabolism in a finishing pig model

L Zhang, F Li, Q Guo, Y Duan, W Wang… - Journal of Agricultural …, 2021 - ACS Publications
This study aimed to investigate the effect of the supplementation of branched-chain amino
acids (BCAAs) at different ratios in protein restriction diets on lipid metabolism in a finishing …

Leucine in obesity: therapeutic prospects

K Yao, Y Duan, F Li, B Tan, Y Hou, G Wu… - Trends in pharmacological …, 2016 - cell.com
Obesity develops from an imbalance of energy homeostasis and is associated with chronic
low-grade inflammation in white adipose tissues (WAT). Inflammation is involved in the …

Gut microbiota mediates the protective effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) against obesity induced by high‐fat diets

Y Duan, Y Zhong, H Xiao, C Zheng, B Song… - The FASEB …, 2019 - Wiley Online Library
Obesity increases the risk of developing insulin resistance and diabetes and is a major
public health concern. Our previous study shows that dietary β‐hydroxy‐β‐methylbutyrate …

Development of therapeutics that induce mitochondrial biogenesis for the treatment of acute and chronic degenerative diseases

RB Cameron, CC Beeson… - Journal of medicinal …, 2016 - ACS Publications
Mitochondria have various roles in cellular metabolism and homeostasis. Because
mitochondrial dysfunction is associated with many acute and chronic degenerative …