Pharmacotherapy of obesity: available medications and drugs under investigation
Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …
than half a billion people worldwide. Energy balance and appetite are highly regulated via …
Molecular physiology of membrane guanylyl cyclase receptors
M Kuhn - Physiological reviews, 2016 - journals.physiology.org
Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …
BCAA metabolism and insulin sensitivity–Dysregulated by metabolic status?
NP Gannon, JK Schnuck… - Molecular nutrition & food …, 2018 - Wiley Online Library
Branched‐chain amino acids (BCAAs) appear to influence several synthetic and catabolic
cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most …
cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most …
An update regarding the bioactive compound of cereal by-products: Health benefits and potential applications
Cereal processing generates around 12.9% of all food waste globally. Wheat bran, wheat
germ, rice bran, rice germ, corn germ, corn bran, barley bran, and brewery spent grain are …
germ, rice bran, rice germ, corn germ, corn bran, barley bran, and brewery spent grain are …
Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications
W Jiang, K Ding, R Yue, M Lei - Critical reviews in food science …, 2024 - Taylor & Francis
Diabetes mellitus (DM) is a global health issue in the twenty-first century, and there are
numerous challenges in preventing and alleviating its chronic complications. The herb …
numerous challenges in preventing and alleviating its chronic complications. The herb …
[HTML][HTML] Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK
D Rogacka, I Audzeyenka, M Rychłowski… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Podocyte insulin sensitivity is critical for glomerular function, and the loss of appropriate
insulin signaling leads to alterations and disorders featuring diabetic nephropathy. Energy …
insulin signaling leads to alterations and disorders featuring diabetic nephropathy. Energy …
Different proportions of branched-chain amino acids modulate lipid metabolism in a finishing pig model
L Zhang, F Li, Q Guo, Y Duan, W Wang… - Journal of Agricultural …, 2021 - ACS Publications
This study aimed to investigate the effect of the supplementation of branched-chain amino
acids (BCAAs) at different ratios in protein restriction diets on lipid metabolism in a finishing …
acids (BCAAs) at different ratios in protein restriction diets on lipid metabolism in a finishing …
Leucine in obesity: therapeutic prospects
Obesity develops from an imbalance of energy homeostasis and is associated with chronic
low-grade inflammation in white adipose tissues (WAT). Inflammation is involved in the …
low-grade inflammation in white adipose tissues (WAT). Inflammation is involved in the …
Gut microbiota mediates the protective effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) against obesity induced by high‐fat diets
Y Duan, Y Zhong, H Xiao, C Zheng, B Song… - The FASEB …, 2019 - Wiley Online Library
Obesity increases the risk of developing insulin resistance and diabetes and is a major
public health concern. Our previous study shows that dietary β‐hydroxy‐β‐methylbutyrate …
public health concern. Our previous study shows that dietary β‐hydroxy‐β‐methylbutyrate …
Development of therapeutics that induce mitochondrial biogenesis for the treatment of acute and chronic degenerative diseases
RB Cameron, CC Beeson… - Journal of medicinal …, 2016 - ACS Publications
Mitochondria have various roles in cellular metabolism and homeostasis. Because
mitochondrial dysfunction is associated with many acute and chronic degenerative …
mitochondrial dysfunction is associated with many acute and chronic degenerative …