Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a
powerful karyotyping tool in numerous translational cancer studies. SNP-A complements …

Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic
abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL) …

Most children with acute lymphoblastic leukemia (ALL) can be cured, but the prognosis is
dismal for the minority of patients who relapse after treatment. To explore the genetic basis …

The analysis of rare chromosomal translocations in myeloproliferative disorders has
highlighted the importance of aberrant tyrosine kinase signaling in the pathogenesis of …

Using metaphase cytogenetics (MC), chromosomal abnormalities are found in only a
proportion of patients with myelodysplastic syndrome (MDS). We hypothesized that with new …

Although a number of genes related to melanoma development have been identified
through candidate gene screening approaches, few studies have attempted to conduct such …

The use of combination chemotherapy to cure acute lymphoblastic leukaemia (ALL) in
children emerged in the 1980s as a paradigm for curing any disseminated cancer, and many …

Inactivation of the tumor suppressor gene, CDKN2A, can occur by deletion, methylation, or
mutation. We assessed the principal mode of inactivation in childhood acute lymphoblastic …

The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia
(ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed …

Until recently, our understanding of the genetic factors contributing to the pathogenesis of
acute lymphoblastic leukemia (ALL) has relied on the detection of gross chromosomal …