The emergence of genetic engineering at the beginning of the 1970′ s opened the era of
biomedical technologies, which aims to improve human health using genetic manipulation …

Introduction: Lentiviruses are a very potent class of viral vectors for which there is presently a
rapidly growing interest for a number of gene therapy. However, their construction …

Retroviruses rely on host RNA-binding proteins to modulate various steps in their
replication. Previously several animal retroviruses were determined to mediate Dhx9/RNA …

Retroviruses have evolved multiple strategies to direct the synthesis of a complex proteome
from a single primary transcript. Their mechanisms are modulated by a breadth of virus-host …

Despite the extensive research efforts over the past 25 years that have focused on HIV, there
is still no cure for AIDS. However, tremendous progress in the understanding of the structure …

Abstract The 5′ untranslated region (UTR) of retroviruses contain structured replication
motifs that impose barriers to efficient ribosome scanning. Two RNA structural motifs that …

The practical application of gene transfer as a treatment for genetic diseases such as cystic
fibrosis or hemophilia has been hindered, in part, by low efficiencies of vector delivery and …

We have shown that the receptor tyrosine kinase ErbB4 signals neuregulin1-stimulated
proliferation of human cells. Some isoforms of ErbB4 are cleaved to release the soluble …

Recently, RNA helicase A (RHA) has been shown to facilitate translation of specific mRNAs
by recognizing and binding to a complex structure at their 5′ end known as the post …

Lentiviruses are a genus of the family Retroviridae (retroviruses)[1] that have been modified
to be used as gene transfer agents.“Lenti-,” from the Latin for “slow,” refers to the wellknown …