Wound healing: cellular mechanisms and pathological outcomes

HN Wilkinson, MJ Hardman - Open biology, 2020 - royalsocietypublishing.org
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

[HTML][HTML] Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

S Patel, S Srivastava, MR Singh, D Singh - Biomedicine & …, 2019 - Elsevier
Wound management in diabetic patient is of an extreme clinical and social concern. The
delayed and impaired healing makes it more critical for research focus. The research on …

The treatment of impaired wound healing in diabetes: looking among old drugs

SF Spampinato, GI Caruso, R De Pasquale… - Pharmaceuticals, 2020 - mdpi.com
Chronic wounds often occur in patients with diabetes mellitus due to the impairment of
wound healing. This has negative consequences for both the patient and the medical …

[HTML][HTML] Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration

H Wang, X Chang, Q Ma, B Sun, H Li, J Zhou, Y Hu… - Bioactive Materials, 2023 - Elsevier
Diabetes mellitus (DM) aggravates periodontitis, resulting in accelerated periodontal bone
resorption. Disordered glucose metabolism in DM causes reactive oxygen species (ROS) …

Biomimetic hydrogel for rapid and scar-free healing of skin wounds inspired by the healing process of oral mucosa

X Kong, J Fu, K Shao, L Wang, X Lan, J Shi - Acta biomaterialia, 2019 - Elsevier
Inspired by the wound healing characteristics of the oral mucosa, a biomimetic hydrogel was
prepared to realize the rapid and scar-free healing of skin wounds. Through monitoring the …

Procyanidin B2 improves endothelial progenitor cell function and promotes wound healing in diabetic mice via activating Nrf2

J Fan, H Liu, J Wang, J Zeng, Y Tan… - Journal of Cellular …, 2021 - Wiley Online Library
One of the major reasons for the delayed wound healing in diabetes is the dysfunction of
endothelial progenitor cells (EPCs) induced by hyperglycaemia. Improvement of EPC …

Characterization of diabetic and non-diabetic foot ulcers using single-cell RNA-sequencing

M Januszyk, K Chen, D Henn, DS Foster, MR Borrelli… - Micromachines, 2020 - mdpi.com
Background: Recent advances in high-throughput single-cell sequencing technologies have
led to their increasingly widespread adoption for clinical applications. However, challenges …

The role of dipeptidyl peptidase‐4 in cutaneous disease

PM Patel, VA Jones, K Kridin… - Experimental …, 2021 - Wiley Online Library
Abstract Dipeptidyl peptidase‐4 (DPP4) is a multifunctional, transmembrane glycoprotein
present on the cell surface of various tissues. It is present in multiple molecular forms …

Nanofibrous vildagliptin/PLGA membranes accelerate diabetic wound healing by angiogenesis

CH Lee, CH Huang, KC Hung, SC Huang, CC Kuo… - Pharmaceuticals, 2022 - mdpi.com
The inhibition of dipeptidyl peptidase-4 (DPP4) significantly enhances the wound closure
rate in diabetic patients with chronic foot ulcers. DPP4 inhibitors are only prescribed for …

Targeting cluster of differentiation 26/dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis

B Ohm, I Moneke… - British Journal of …, 2023 - Wiley Online Library
Cluster of differentiation 26 (CD26)/dipeptidyl peptidase 4 (DPP4) is an exopeptidase that is
expressed as a transmembrane protein in many organs but also present in a circulating …