The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-
cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a …

Abstract β-Carboline alkaloids are a family of natural and synthetic products with structural
diversity and outstanding antitumor activities. This review summarizes research …

An unprecedented example of a chiral phosphoric acid‐catalyzed atroposelective Pictet–
Spengler reaction of N‐arylindoles is reported. Highly enantioenriched N‐aryl‐tetrahydro‐β …

Cancer is a huge burden on the healthcare system and is foremost cause of mortality across
the globe. Among various therapeutic strategies, chemotherapy plays an enormous role in …

The discovery of antifungal agents with novel structure, broad-spectrum, low toxicity, and
high efficiency has been the focus of medicinal chemists. Over the past decades, β-carboline …

Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of
biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several …

The platinum-based complexes were the first anticancer metallotherapeutics to emerge and
since their discovery several other coordination compounds consisting of transition metal …

Piperazine scaffolds are a group of heterocyclic atoms having pharmacological values and
showing significant results in pharmaceutical chemistry. Piperazine has a flexible core …

A new series of benzimidazole/benzoxazole linked β-carbolines (9a-j) were rationally
designed and synthesized by combining two different anti-cancer fragments. The new hybrid …

Myeloid cell leukemia 1 (Mcl-1), which belongs to the Bcl-2 family of prosurvival proteins, is
a key regulator of cancer cell survival. To date, few drug-like Mcl-1 inhibitors have been …