[HTML][HTML] Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

[HTML][HTML] Transcriptional and epigenetic regulation of monocyte and macrophage dysfunction by chronic alcohol consumption

DC Malherbe, I Messaoudi - Frontiers in immunology, 2022 - frontiersin.org
Drinking alcohol, even in moderation, can affect the immune system. Studies have shown
disproportionate effects of alcohol on circulating and tissue-resident myeloid cells …

[HTML][HTML] Recent advances in understanding of pathogenesis of alcohol-associated liver disease

X Wu, X Fan, T Miyata, A Kim… - Annual Review of …, 2023 - annualreviews.org
Alcohol-associated liver disease (ALD) is one of the major diseases arising from chronic
alcohol consumption and is one of the most common causes of liver-related morbidity and …

[HTML][HTML] Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

X Wu, X Fan, MR McMullen, T Miyata, A Kim… - Hepatology, 2023 - journals.lww.com
Abbreviations: ABCA1, ATP binding cassette subfamily A member; AH, alcohol‐associated
hepatitis; ALD, alcohol‐associated liver disease; BMDM, bone marrow–derived …

A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues

K Crotty, P Anton, LG Coleman… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Alcohol misuse contributes to the dysregulation of immune responses and multiorgan
dysfunction across various tissues, which are associated with higher risk of morbidity and …

Gene deconvolution reveals aberrant liver regeneration and immune cell infiltration in alcohol‐associated hepatitis

A Kim, X Wu, DS Allende, LE Nagy - Hepatology, 2021 - Wiley Online Library
Background and Aims Acute liver damage causes hepatocyte stress and death, but in
chronic liver disease impaired hepatocyte regeneration and immune cell infiltration prevents …

[HTML][HTML] Hepatic toxicity of fluorene-9-bisphenol (BHPF) on CD-1 mice

L Yang, X Guo, X Mao, X Jia, Y Zhou, Y Hu… - Ecotoxicology and …, 2021 - Elsevier
Abstract Fluorene-9-bisphenol (BHPF), a substitute for bisphenol A (BPA), has been widely
used in the synthesis of polyester polymers. Studies have reported multiple BHPF toxicities …

[HTML][HTML] Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury

Q Zhang, W Liu, K Bulek, H Wang… - Hepatology …, 2023 - journals.lww.com
Background: Macrophage-inducible C-type lectin (Mincle) is expressed on hepatic
macrophages and senses ethanol (EtOH)-induced danger signals released from dying …

Gut-liver Axis: Recent concepts in pathophysiology in alcohol-associated liver disease

FR Tonetti, A Eguileor, M Mrdjen, V Pathak… - Hepatology, 2024 - journals.lww.com
The growing recognition of the role of the gut microbiome's impact on alcohol-related
diseases, especially in alcohol-associated liver disease, emphasizes the need to …

[HTML][HTML] Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis

X Liu, ZX Liu, TR Morgan, TM Norden-Krichmar - Human Immunology, 2024 - Elsevier
Alcohol-associated hepatitis (AH) is often diagnosed at advanced stages, and severe AH
usually carries poor prognosis and high short-term mortality. In addition, it is challenging to …