Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …

Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

Drug design in recent years has attempted to explore new chemical spaces resulting in
more complex, larger molecular weight molecules, often with limited water solubility. To …

In this extensive review, we elucidate the importance of proteases and their role in drug
development in various diseases with an emphasis on cancer. First, key proteases are …

Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for
human use. Because of the occurrence of Cremophor EL anaphylaxis and improvements in …

Completely revised and updated, this third edition of Pharmaceutical Dosage Forms and
Drug Delivery elucidates the basic principles of pharmaceutics, biopharmaceutics, dosage …

Bacterial infections are raising serious concern across the globe. The effectiveness of
conventional antibiotics is decreasing due to global emergence of multi-drug-resistant …

Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a
parent drug in the body. In the past, prodrugs were used as a last option; however …

Central nervous system (CNS) drug delivery remains a major challenge, despite extensive
efforts that have been made to develop novel strategies to overcome obstacles. Prodrugs …