Epithelial-to-mesenchymal transition (EMT) is a self-regulated physiological process
required for tissue repair that, in non-controled conditions may lead to fibrosis …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling
of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and …

Abstract Ethno Pharmacological Relevance: Traditional medicinal plants are practiced
worldwide for treatment of arthritis especially in developing countries where resources are …

Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …

Celastrol is a bioactive compound derived from traditional Chinese medicinal herbs of the
Celastraceae family. Celastrol is known to possess anti-inflammatory and anti-oxidant …

Signaling via the phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) is crucial for divergent physiological processes including transcription, translation …

Cumulative evidences (s) have established that the constitutive activation of STAT3 plays a
pivotal role in the proliferation, survival, metastasis, and angiogenesis and thus can …

Inflammation is an integral component of autoimmune arthritis. The balance of pathogenic T
helper 17 (Th17) and protective T regulatory (Treg) cells can influence disease severity, and …

Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine”, is known to have
anticancer activity, but its underlying mechanism is not completely understood. In this study …