The role of the CXCL12/CXCR4/CXCR7 chemokine axis in cancer
Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
CXCL12 (SDF-1)/CXCR4 pathway in cancer
BA Teicher, SP Fricker - Clinical cancer research, 2010 - AACR
Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-
coupled seven-span transmembrane receptors, are major regulators of cell trafficking and …
coupled seven-span transmembrane receptors, are major regulators of cell trafficking and …
[HTML][HTML] A review on CXCR4/CXCL12 axis in oncology: no place to hide
UM Domanska, RC Kruizinga, WB Nagengast… - European journal of …, 2013 - Elsevier
Classical chemotherapeutic anti-cancer treatments induce cell death through DNA damage
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …
Cancer-related inflammation
A Mantovani, P Allavena, A Sica, F Balkwill - nature, 2008 - nature.com
The mediators and cellular effectors of inflammation are important constituents of the local
environment of tumours. In some types of cancer, inflammatory conditions are present before …
environment of tumours. In some types of cancer, inflammatory conditions are present before …
CXCR4 in breast cancer: oncogenic role and therapeutic targeting
C Xu, H Zhao, H Chen, Q Yao - Drug design, development and …, 2015 - Taylor & Francis
Chemokines are 8–12 kDa peptides that function as chemoattractant cytokines and are
involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G …
involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G …
Molecular pathways linking inflammation and cancer
A Mantovani - Current molecular medicine, 2010 - ingentaconnect.com
Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory
component is present also in the microenvironment of tumours that are not epidemiologically …
component is present also in the microenvironment of tumours that are not epidemiologically …
CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
A Mousavi - Immunology Letters, 2020 - Elsevier
Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …
[HTML][HTML] Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies
RC Smallridge, LA Marlow… - Endocrine-related …, 2009 - erc.bioscientifica.com
Anaplastic thyroid cancer (ATC) is a rare malignancy. While external beam radiation therapy
has improved locoregional control, the median survival of∼ 4 months has not changed in …
has improved locoregional control, the median survival of∼ 4 months has not changed in …
CXCR4 and cancer
B Furusato, JS Rhim - Chemokine Receptors in Cancer, 2009 - Springer
The chemokine receptor CXCR4 belongs to the large superfamily of G-protein-coupled
receptors, and is directly involved in a number of biological processes including …
receptors, and is directly involved in a number of biological processes including …
Molecular pathways in cancer-related inflammation
A Dep Prete, P Allavena, G Santoro, R Fumarulo… - Biochemia …, 2011 - hrcak.srce.hr
Sažetak Accumulating evidence shows that chronic inflammation is associated to increased
risk of cancer. An inflammatory component is present also in the microenvironment of …
risk of cancer. An inflammatory component is present also in the microenvironment of …