Hemocompatibility challenge of membrane oxygenator for artificial lung technology

BPN Thi, BTD Nguyen, IS Jeong, JF Kim - Acta Biomaterialia, 2022 - Elsevier
The artificial lung (AL) technology is one of the membrane-based artificial organs that partly
augments lung functions, ie blood oxygenation and CO 2 removal. It is generally employed …

The microfluidic artificial lung: Mimicking nature's blood path design to solve the biocompatibility paradox

TL Astor, JT Borenstein - Artificial Organs, 2022 - Wiley Online Library
The increasing prevalence of chronic lung disease worldwide, combined with the
emergence of multiple pandemics arising from respiratory viruses over the past century …

An artificial placenta type microfluidic blood oxygenator with double-sided gas transfer microchannels and its integration as a neonatal lung assist device

M Dabaghi, G Fusch, N Saraei, N Rochow, JL Brash… - …, 2018 - pubs.aip.org
Preterm neonates suffering from respiratory distress syndrome require assistive support in
the form of mechanical ventilation or extracorporeal membrane oxygenation, which may …

Structure-dependent gas transfer performance of 3D-membranes for artificial membrane lungs

F Hesselmann, N Scherenberg, P Bongartz… - Journal of Membrane …, 2021 - Elsevier
State of the art artificial membrane lungs incorporate hollow fiber membranes. The creeping
blood flow in hollow fiber bundles forms a boundary layer that represents a diffusive …

Design analysis and optimization of a single-layer PDMS microfluidic artificial lung

AJ Thompson, LJ Ma, TJ Plegue… - IEEE Transactions on …, 2018 - ieeexplore.ieee.org
Objective: Microfluidic artificial lungs (μALs) are being researched for future clinical use due
to the potential for increased gas exchange efficiency, small blood contacting surface area …

An ultra-thin highly flexible microfluidic device for blood oxygenation

M Dabaghi, N Saraei, G Fusch, N Rochow, JL Brash… - Lab on a Chip, 2018 - pubs.rsc.org
Many neonates who are born premature suffer from respiratory distress syndrome (RDS) for
which mechanical ventilation and an extracorporeal membrane oxygenation (ECMO) device …

An ultra-thin, all PDMS-based microfluidic lung assist device with high oxygenation capacity

M Dabaghi, N Saraei, G Fusch, N Rochow, JL Brash… - …, 2019 - pubs.aip.org
Preterm neonates with immature lungs require a lung assist device (LAD) to maintain
oxygen saturation at normal levels. Over the last decade, microfluidic blood oxygenators …

Assessing and improving the biocompatibility of microfluidic artificial lungs

AJ Thompson, LJ Ma, T Major, M Jeakle… - Acta biomaterialia, 2020 - Elsevier
Microfluidic artificial lungs (µALs) have the potential to improve the treatment and quality of
life for patients with acute or chronic lung injury. In order to realize the full potential of this …

A pumpless microfluidic neonatal lung assist device for support of preterm neonates in respiratory distress

M Dabaghi, N Rochow, N Saraei, G Fusch… - Advanced …, 2020 - Wiley Online Library
Premature neonates suffer from respiratory morbidity as their lungs are immature, and
current supportive treatment such as mechanical ventilation or extracorporeal membrane …

The separation membranes in artificial organs

D Sheng, X Li, C Sun, J Zhou, X Feng - Materials Chemistry Frontiers, 2023 - pubs.rsc.org
Separation membranes play a crucial role in the functioning of artificial organs, such as
hemodialysis machines, membrane oxygenators, and artificial liver models. The current …