Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

Inducing fetal hemoglobin (HbF) in red blood cells can alleviate β-thalassemia and sickle
cell disease. We compared five strategies in CD34+ hematopoietic stem and progenitor …

The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …

Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …

Mass spectrometry-based proteomics now enables the absolute quantification of thousands
of proteins in individual cell types. We used this technology to analyze the dynamic …

Histology refers to the study of the morphology of cells within their natural tissue
environment. As a bio‐medical discipline, it dates back to the development of first …

Gene editing the BCL11A erythroid enhancer is a validated approach to fetal hemoglobin
(HbF) induction for β-hemoglobinopathy therapy, though heterogeneity in edit allele …

Although originally described as transcriptional activator, SPI1/PU. 1, a major player in
haematopoiesis whose alterations are associated with haematological malignancies, has …

Regulating transcription allows organisms to respond to their environment, both within a
single generation (plasticity) and across generations (adaptation). We examined …

Background The spleen is the largest secondary lymphoid organ and the main site where
stress erythropoiesis occurs. It is known that hypoxia triggers the expansion of erythroid …