Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …

Despite the introduction of numerous biologic agents for the treatment of rheumatoid arthritis
(RA) and other forms of inflammatory arthritis, low-dose methotrexate therapy remains the …

TP53-mutated myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) form a
distinct group of myeloid disorders with dismal outcomes. TP53-mutated MDS and AML …

The design of bioactive supramolecular chirality is always hampered by the lack of feasible
schemes to assigned specific biological activities. Herein, we developed a “mirror-image …

Owing to their tremendous diversity and plasticity, immune cells exert multifaceted functions
in tumor-bearing hosts, ranging from anti-tumor to pro-tumor activities. Tumor immune …

Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-
survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a
variety of tumors, but resistance during treatment is a major issue. In this review, we describe …