Recommendations for the management of hemophagocytic lymphohistiocytosis in adults

P La Rosée, AC Horne, M Hines… - Blood, The Journal …, 2019 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …

Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: recommendations from the North American Consortium for Histiocytosis (NACHO)

MB Jordan, CE Allen, J Greenberg… - Pediatric blood & …, 2019 - Wiley Online Library
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …

[HTML][HTML] Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome

MR Hines, TE Knight, KO McNerney, MB Leick… - … and Cellular Therapy, 2023 - Elsevier
Background T cell mediated hyperinflammatory responses such as cytokine release
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …

Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy

G Griffin, S Shenoi, GC Hughes - Best Practice & Research Clinical …, 2020 - Elsevier
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

Hemophagocytic lymphohistiocytosis

H Al-Samkari, N Berliner - Annual review of pathology …, 2018 - annualreviews.org
Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by
unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages …

Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment

SJ Carter, RS Tattersall, AV Ramanan - Rheumatology, 2019 - academic.oup.com
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which if not
promptly treated, can lead rapidly to critical illness and death. HLH is termed macrophage …

How I treat hemophagocytic lymphohistiocytosis in the adult patient

AM Schram, N Berliner - Blood, The Journal of the American …, 2015 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a devastating disorder of uncontrolled
immune activation characterized by clinical and laboratory evidence of extreme …

Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry

S Birndt, T Schenk, B Heinevetter… - Journal of cancer …, 2020 - Springer
Purpose Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory
syndrome emerging from a deregulated immune response due to various triggers. In adults …

[HTML][HTML] Hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) in adults: a systematic scoping review

A Hayden, S Park, D Giustini, AYY Lee, LYC Chen - Blood reviews, 2016 - Elsevier
Most knowledge of hemophagocytic syndromes (HPSs) including hemophagocytic
lymphohistiocytosis (HLH) is derived from pediatric studies; literature on adult HPS/HLH …

Adult-onset Still's disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers

P Ruscitti, P Cipriani, F Masedu, D Iacono, F Ciccia… - BMC medicine, 2016 - Springer
Abstract Background Adult-onset Still's disease (AOSD) is rare inflammatory disease of
unknown etiology that usually affects young adults. The more common clinical …