Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to
administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery …

During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4
MPa and 31.1° C. Given the request for consumption of a green solvent for the environment …

The loading of polymeric carriers with active pharmaceutical and nutraceutical ingredients
using supercritical CO 2 (scCO 2) as solvent and diffusion enhancer has received increasing …

Oral administration of drugs is most convenient for patients and therefore the ultimate goal
when developing new medication. The physical barriers in the body, low pH of the stomach …

This work explores the potential of polymeric micrometer sized devices (microcontainers) as
oral drug delivery systems (DDS). Arrays of detachable microcontainers (D-MCs) were …

This article reviews the use of fluids under supercritical conditions in processes related to
the modern and innovative polymer industry. The most important processes using …

Ketoprofen (KET) is an anti-inflammatory drug often used in medicine due to its analgesic
and antipyretic effects. If it is administered in a controlled form by means of different dosing …

Supercritical carbon dioxide has been used as a green solvent due to their well-known
potential in biomaterials impregnation. The versatility of this technique enables the loading …