Osteochondral defect management and repair remain a significant challenge in orthopedic
surgery. Osteochondral defects contain damage to both the articular cartilage as well as the …

Background The management of articular cartilage defects presents many clinical
challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation …

For 3D bioprinted tissues to be scaled-up to clinically relevant sizes, effective
prevascularisation strategies are required to provide the necessary nutrients for normal …

Successful tissue engineering requires the generation of human scale implants that mimic
the structure, composition and mechanical properties of native tissues. Here, we report a …

Articular cartilage has a limited capacity to repair following injury. Early intervention is
required to prevent progression of focal traumatic chondral and osteochondral defects to …

The majority of synthetic polymers used in 3 D printing are not designed to promote specific
cellular interactions and hence possess limited bioactivity. Most of the strategies proposed to …

Articular cartilage repair is a sophisticated process that has is being recently investigated.
There are several different approaches that are currently reported to promote cartilage …

Chondrogenically primed bone marrow-derived mesenchymal stem cells (MSCs) have been
shown to become hypertrophic and undergo endochondral ossification when implanted in …

Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) have been shown
to generate bone in vivo by executing an endochondral programme. This may hinder the …

Cartilage defects are a predisposing factor for osteoarthritis. Conventional therapies are
mostly palliative and there is an interest in developing newer therapies that target the …