Targeting metalloenzymes for therapeutic intervention
AY Chen, RN Adamek, BL Dick, CV Credille… - Chemical …, 2018 - ACS Publications
Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease
CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …
their potential against several of the world's most important neglected tropical diseases …
Design, synthesis and biological evaluation of substituted 3-amino-N-(thiazol-2-yl) pyrazine-2-carboxamides as inhibitors of mycobacterial methionine …
M Juhás, VSK Pallabothula, K Grabrijan… - Bioorganic …, 2022 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is the number one cause of
deaths due to a single infectious agent worldwide. The treatment of TB is lengthy and often …
deaths due to a single infectious agent worldwide. The treatment of TB is lengthy and often …
High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase
The emergence of drug-resistant strains of Mycobacterium tuberculosis makes identification
and validation of newer drug targets a global priority. Phosphoserine phosphatase (PSP), a …
and validation of newer drug targets a global priority. Phosphoserine phosphatase (PSP), a …
Advances in bacterial methionine aminopeptidase inhibition
TR Helgren, P Wangtrakuldee… - Current topics in …, 2016 - ingentaconnect.com
Methionine aminopeptidases (MetAPs) are metalloenzymes that cleave the N-terminal
methionine from newly synthesized peptides and proteins. These MetAP enzymes are …
methionine from newly synthesized peptides and proteins. These MetAP enzymes are …
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and …
Abstract Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes
that are responsible for the cleavage of the initiator Methionine from the nascent …
that are responsible for the cleavage of the initiator Methionine from the nascent …
Antibacterial epipolythiodioxopiperazine and unprecedented sesquiterpene from Pseudallescheria boydii, a beetle (coleoptera)-associated fungus
Q Wu, N Jiang, WB Han, YN Mei, HM Ge… - Organic & …, 2014 - pubs.rsc.org
Pseudallescheria boydii residing in the gut of coleopteran (Holotrichia parallela) larva
produces four new epipolythiodioxopiperazine (ETP) boydines A–D (3–6) and two novel …
produces four new epipolythiodioxopiperazine (ETP) boydines A–D (3–6) and two novel …
Attempting Well-Tempered Funnel Metadynamics Simulations for the Evaluation of the Binding Kinetics of Methionine Aminopeptidase-II Inhibitors
Understanding the unbinding kinetics of protein–ligand complexes is considered a
significant approach for the design of ligands with desired specificity and safety. In recent …
significant approach for the design of ligands with desired specificity and safety. In recent …
Identification of a Cryptic Pocket in Methionine Aminopeptidase-II Using Adaptive Bandit Molecular Dynamics Simulations and Markov State Models
Methionine aminopeptidase-II (MetAP-II) is a metalloprotease, primarily responsible for the
cotranslational removal of the N-terminal initiator methionine from the nascent polypeptide …
cotranslational removal of the N-terminal initiator methionine from the nascent polypeptide …
Diketo acids and their amino acid/dipeptidic analogues as promising scaffolds for the development of bacterial methionine aminopeptidase inhibitors
Using diketoesters as the template, various derivatives were designed and the selected
compounds were synthesized as bacterial methionine aminopeptidase (MetAP) inhibitors …
compounds were synthesized as bacterial methionine aminopeptidase (MetAP) inhibitors …