Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor
prognosis, short median patient survival and a very limited response to therapies. GBM has …

Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system,
characterized by an extremely aggressive clinical phenotype. Patients with GBM have a …

Glioblastoma (GBM) is the most aggressive and common form of brain cancer in adults.
GBM is characterized by poor survival and remarkably high tumors heterogeneity (both …

Glioblastoma is the most common and most aggressive diffuse glioma, associated with short
survival and uniformly fatal outcome, irrespective of treatment. It is characterized by …

G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …

In recent years, important advances have been achieved in the understanding of the
molecular biology of glioblastoma multiforme (GBM); thus, complex genetic alterations and …

Immunotherapy has enabled remarkable therapeutic responses across cancers of various
lineages, albeit with some notable exceptions such as glioblastoma. Several previous …

Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about
half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR …

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …

Background The efficacy of novel targeted therapies is often tested at the time of tumor
recurrence. However, for glioblastoma (GBM) patients, surgical resections at recurrence are …