Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …

The DNA-dependent protein kinase (DNA-PK) is a pivotal component of the DNA repair
machinery that governs the response to DNA damage, serving to maintain genome integrity …

Radiation therapy is a staple cancer treatment approach that has significantly improved local
disease control and the overall survival of cancer patients. However, its efficacy is still limited …

Radiation therapy (RT) is a standard treatment for solid tumors and about 50% of patients
with cancer, including pediatric cancer, receive RT. While RT has significantly improved the …

Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …

Radioprotectors are agents required to protect biological system exposed to radiation, either
naturally or through radiation leakage, and they protect normal cells from radiation injury in …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase
that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression …

Background DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel
instigator for mitochondrial dysfunction, and plays an important role in the pathogenesis of …

Radiotherapy is one of the most common treatment modalities for controlling a wide range of
tumors. However, it has been shown that radiotherapy alone is unable to completely …