Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges

RM Shallis, R Wang, A Davidoff, X Ma, AM Zeidan - Blood reviews, 2019 - Elsevier
Acute myeloid leukemia (AML) is a malignant disorder of the bone marrow which is
characterized by the clonal expansion and differentiation arrest of myeloid progenitor cells …

[HTML][HTML] Targeting FLT3 mutations in AML: review of current knowledge and evidence

N Daver, RF Schlenk, NH Russell, MJ Levis - Leukemia, 2019 - nature.com
Genomic investigations of acute myeloid leukemia (AML) have demonstrated that several
genes are recurrently mutated, leading to new genomic classifications, predictive …

Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: long term follow‐up from a phase 1b study

DA Pollyea, K Pratz, A Letai, BA Jonas… - American journal of …, 2021 - Wiley Online Library
This analysis represents the longest‐term follow‐up for patients with acute myeloid leukemia
(AML) treated with 400 mg of venetoclax plus azacitidine or decitabine. Adults with newly …

[HTML][HTML] Research progress on dendritic cell vaccines in cancer immunotherapy

J Yu, H Sun, W Cao, Y Song, Z Jiang - Experimental hematology & …, 2022 - Springer
Dendritic cell (DC) vaccines induce specific immune responses that can selectively
eliminate target cells. In recent years, many studies have been conducted to explore DC …

Acute myeloid leukemia: 2019 update on risk‐stratification and management

EH Estey - American journal of hematology, 2018 - Wiley Online Library
Outcome in patients with acute myeloid leukemia (AML) ranges from death within a few days
of beginning treatment (treatment related mortality, TRM) to likely cure. The major reason …

[HTML][HTML] The clinical impact of the molecular landscape of acute myeloid leukemia

S Kayser, MJ Levis - Haematologica, 2023 - ncbi.nlm.nih.gov
Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has
led to remarkable advances in our understanding of the disease. Mutations now allow us to …

[HTML][HTML] Measurable residual disease at induction redefines partial response in acute myeloid leukemia and stratifies outcomes in patients at standard risk without …

SD Freeman, RK Hills, P Virgo, N Khan… - Journal of Clinical …, 2018 - ncbi.nlm.nih.gov
Purpose We investigated the effect on outcome of measurable or minimal residual disease
(MRD) status after each induction course to evaluate the extent of its predictive value for …

[HTML][HTML] CD123 as a therapeutic target in the treatment of hematological malignancies

U Testa, E Pelosi, G Castelli - Cancers, 2019 - mdpi.com
The interleukin-3 receptor alpha chain (IL-3Rα), more commonly referred to as CD123, is
widely overexpressed in various hematological malignancies, including acute myeloid …

FLT3 inhibitors in acute myeloid leukemia: challenges and recent developments in overcoming resistance

Z Wang, J Cai, J Cheng, W Yang, Y Zhu… - Journal of Medicinal …, 2021 - ACS Publications
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are often present in newly
diagnosed acute myeloid leukemia (AML) patients with an incidence rate of approximately …

[HTML][HTML] CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p–XIAP axis

J Shang, WM Chen, ZH Wang, TN Wei, ZZ Chen… - Experimental …, 2019 - Elsevier
The contribution and role of circular RNAs (circRNAs) in mediating chemoresistance in
acute myeloid leukemia (AML) are still poorly understood and need further investigation. In …