TRPV1-targeted drugs in development for human pain conditions

M Iftinca, M Defaye, C Altier - Drugs, 2021 - Springer
The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

Capsaicin—The major bioactive ingredient of chili peppers: Bio-efficacy and delivery systems

M Lu, C Chen, Y Lan, J Xiao, R Li, J Huang, Q Huang… - Food & function, 2020 - pubs.rsc.org
Capsaicin is the primary bioactive substance in red chili peppers, which produces the
pungent flavor. During the past few decades, pharmacological benefits of capsaicin and its …

Encapsulation of hydrophobic capsaicin within the aqueous phase of water-in-oil high internal phase emulsions: Controlled release, reduced irritation, and enhanced …

X Wu, N Xu, C Cheng, DJ McClements, X Chen, L Zou… - Food …, 2022 - Elsevier
Capsaicin (CAP) is a hydrophobic substance with various physiological effects in chili
peppers that is responsible for their perceived heat. Nonetheless, its application as a …

Molecular characterization of capsaicin binding interactions with ovalbumin and casein

MA Razzak, SJ Cho - Food Hydrocolloids, 2022 - Elsevier
Capsaicin (CAP) rich diets may help with a variety of human pathophysiological conditions;
however, CAP administration is difficult due to its high pungency and limited water solubility …

[HTML][HTML] Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications

HJ Lu, XB Wu, QQ Wei - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent
diseases, and current treatments rely primarily on opioids, which have significant side …

Impact of capsaicin on aroma release and perception from flavoured solutions

N Yang, Q Yang, J Chen, I Fisk - LWT, 2021 - Elsevier
Capsaicin is the main component in chilli pepper, which contributes to the spiciness of the
food. However, the role of capsaicin on aroma perception has been controversial in the …

Taste disorders following cancer treatment: report of a case series

JB Epstein, SM de Andrade e Silva, GL Epstein… - Supportive Care in …, 2019 - Springer
Purpose To present the findings of combined oral assessment and gustometry testing of a
series of head and neck and hematologic malignancies in patients with self-reported taste …

Factors explaining individual differences in the oral perception of capsaicin, l‐menthol, and aluminum ammonium sulfate

S Roukka, S Puputti, H Aisala, U Hoppu… - Clinical and …, 2023 - Wiley Online Library
This research focused on the oral perception of naturally occurring chemical food
compounds that are used in the pharma and food industries due to their pharmacological …

[HTML][HTML] In silico drug repurposing framework predicts repaglinide, agomelatine and protokylol as TRPV1 modulators with analgesic activity

C Andrei, DP Mihai, A Zanfirescu, GM Nitulescu… - Pharmaceutics, 2022 - mdpi.com
Pain is one of the most common symptoms experienced by patients. The use of current
analgesics is limited by low efficacy and important side effects. Transient receptor potential …

[HTML][HTML] Peri-threshold trigeminal stimulation with capsaicin increases taste sensitivity in humans

P Han, L Müller, T Hummel - Chemosensory Perception, 2022 - Springer
Introduction Taste perception is affected by trigeminal stimuli, ie, capsaicin. This has been
studied at suprathreshold concentrations. However, little is known about taste perception at …