TRPV1-targeted drugs in development for human pain conditions
The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …
Capsaicin—The major bioactive ingredient of chili peppers: Bio-efficacy and delivery systems
Capsaicin is the primary bioactive substance in red chili peppers, which produces the
pungent flavor. During the past few decades, pharmacological benefits of capsaicin and its …
pungent flavor. During the past few decades, pharmacological benefits of capsaicin and its …
Encapsulation of hydrophobic capsaicin within the aqueous phase of water-in-oil high internal phase emulsions: Controlled release, reduced irritation, and enhanced …
X Wu, N Xu, C Cheng, DJ McClements, X Chen, L Zou… - Food …, 2022 - Elsevier
Capsaicin (CAP) is a hydrophobic substance with various physiological effects in chili
peppers that is responsible for their perceived heat. Nonetheless, its application as a …
peppers that is responsible for their perceived heat. Nonetheless, its application as a …
Molecular characterization of capsaicin binding interactions with ovalbumin and casein
Capsaicin (CAP) rich diets may help with a variety of human pathophysiological conditions;
however, CAP administration is difficult due to its high pungency and limited water solubility …
however, CAP administration is difficult due to its high pungency and limited water solubility …
[HTML][HTML] Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications
HJ Lu, XB Wu, QQ Wei - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent
diseases, and current treatments rely primarily on opioids, which have significant side …
diseases, and current treatments rely primarily on opioids, which have significant side …
Impact of capsaicin on aroma release and perception from flavoured solutions
Capsaicin is the main component in chilli pepper, which contributes to the spiciness of the
food. However, the role of capsaicin on aroma perception has been controversial in the …
food. However, the role of capsaicin on aroma perception has been controversial in the …
Taste disorders following cancer treatment: report of a case series
JB Epstein, SM de Andrade e Silva, GL Epstein… - Supportive Care in …, 2019 - Springer
Purpose To present the findings of combined oral assessment and gustometry testing of a
series of head and neck and hematologic malignancies in patients with self-reported taste …
series of head and neck and hematologic malignancies in patients with self-reported taste …
Factors explaining individual differences in the oral perception of capsaicin, l‐menthol, and aluminum ammonium sulfate
S Roukka, S Puputti, H Aisala, U Hoppu… - Clinical and …, 2023 - Wiley Online Library
This research focused on the oral perception of naturally occurring chemical food
compounds that are used in the pharma and food industries due to their pharmacological …
compounds that are used in the pharma and food industries due to their pharmacological …
[HTML][HTML] In silico drug repurposing framework predicts repaglinide, agomelatine and protokylol as TRPV1 modulators with analgesic activity
Pain is one of the most common symptoms experienced by patients. The use of current
analgesics is limited by low efficacy and important side effects. Transient receptor potential …
analgesics is limited by low efficacy and important side effects. Transient receptor potential …
[HTML][HTML] Peri-threshold trigeminal stimulation with capsaicin increases taste sensitivity in humans
Introduction Taste perception is affected by trigeminal stimuli, ie, capsaicin. This has been
studied at suprathreshold concentrations. However, little is known about taste perception at …
studied at suprathreshold concentrations. However, little is known about taste perception at …