Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Transition-metal-catalyzed C–H bond functionalizations have had an enormous influence on
organic synthesis in recent times. However, the use of low-abundance 4d and 5d metals is …

Organometallic reagents and metal catalysts are used ubiquitously in academia and
industry. Not surprisingly, the biological activity and environmental danger of metal …

The electrophilic halogenation of arenes is perhaps the simplest method to prepare aryl
halides, which are important structural motifs in agrochemicals, materials, and …

Herein, a regioselective, late-stage two-step arene halogenation method is reported. We
propose how unusual Ni (I)/(III) catalysis is enabled by a combination of aryl thianthrenium …

Transition metal–catalyzed arene functionalization has been widely used for molecular
synthesis over the past century. In this arena, copper catalysis has long been considered a …

The construction of enzyme-inspired artificial catalysts with enzyme-like active sites and
microenvironment remains a great challenge. Herein, we report a single-atomic-site Co …

Introduction: Late-stage functionalization (LSF) can introduce important chemical groups in
the very last steps of the synthesis. LSF has the potential to speed up the preparation of …