Macrophage-based approaches for cancer immunotherapy
Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in
hematologic malignancies, but its application to solid tumors has proven challenging. This …
hematologic malignancies, but its application to solid tumors has proven challenging. This …
Targeting the CCL2/CCR2 axis in cancer immunotherapy: one stone, three birds?
L Fei, X Ren, H Yu, Y Zhan - Frontiers in immunology, 2021 - frontiersin.org
CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …
The regulation and importance of monocyte chemoattractant protein-1
The regulation and importance of monocyte chemoattractant pr... : Current Opinion in
Hematology The regulation and importance of monocyte chemoattractant protein-1 : Current …
Hematology The regulation and importance of monocyte chemoattractant protein-1 : Current …
Current methods for studying metastatic potential of tumor cells
P Bouchalova, P Bouchal - Cancer cell international, 2022 - Springer
Cell migration and invasiveness significantly contribute to desirable physiological
processes, such as wound healing or embryogenesis, as well as to serious pathological …
processes, such as wound healing or embryogenesis, as well as to serious pathological …
Hyperleukocytosis and leukostasis in acute myeloid leukemia: can a better understanding of the underlying molecular pathophysiology lead to novel treatments?
JP Bewersdorf, AM Zeidan - Cells, 2020 - mdpi.com
Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …
Monocyte chemoattractant protein-1 (MCP-1/CCL2) drives activation of bone remodelling and skeletal metastasis
BS Mulholland, MR Forwood, NA Morrison - Current osteoporosis reports, 2019 - Springer
Abstract Purpose of Review The purpose of this review is to explore the role of monocyte
chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone …
chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone …
Sex differences in macrophage responses to obesity-mediated changes determine migratory and inflammatory traits
KHE Chen, NM Lainez, D Coss - The Journal of Immunology, 2021 - journals.aai.org
The mechanisms whereby obesity differentially affects males and females are unclear.
Because macrophages are functionally the most important cells in obesity-induced …
Because macrophages are functionally the most important cells in obesity-induced …
Prognosis and characterization of immune microenvironment in acute myeloid leukemia through identification of an autophagy-related signature
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that
has an unfavorable outcome and a high rate of relapse. Autophagy plays a vital role in the …
has an unfavorable outcome and a high rate of relapse. Autophagy plays a vital role in the …
Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance
KE Miari, MTS Williams - British Journal of Pharmacology, 2024 - Wiley Online Library
The bone marrow (BM) is the primary site of adult haematopoiesis, where stromal elements
(eg fibroblasts and mesenchymal stem cells [MSCs]) work in concert to support blood cell …
(eg fibroblasts and mesenchymal stem cells [MSCs]) work in concert to support blood cell …
Dendritic cell vaccine of gliomas: challenges from bench to bed
Y Zheng, X Ma, S Feng, H Zhu, X Chen, X Yu… - Frontiers in …, 2023 - frontiersin.org
Gliomas account for the majority of brain malignant tumors. As the most malignant subtype of
glioma, glioblastoma (GBM) is barely effectively treated by traditional therapies (surgery …
glioma, glioblastoma (GBM) is barely effectively treated by traditional therapies (surgery …