Molecular mechanism and prevention strategy of chemotherapy-and radiotherapy-induced ovarian damage

S Kim, SW Kim, SJ Han, S Lee, HT Park… - International Journal of …, 2021 - mdpi.com
Fertility preservation is an emerging discipline, which is of substantial clinical value in the
care of young patients with cancer. Chemotherapy and radiation may induce ovarian …

The impact of chemotherapy on the ovaries: molecular aspects and the prevention of ovarian damage

C Sonigo, I Beau, N Binart, M Grynberg - International journal of …, 2019 - mdpi.com
Cancer treatment, such as chemotherapy, induces early ovarian follicular depletion and
subsequent infertility. In order to protect gametes from the gonadotoxic effects of …

[HTML][HTML] Fertility preservation and post-treatment pregnancies in post-pubertal cancer patients: ESMO Clinical Practice Guidelines

M Lambertini, FA Peccatori, I Demeestere, F Amant… - Annals of oncology, 2020 - Elsevier
Highlights•These ESMO Clinical Practice Guidelines provide recommendations for:○Fertility
preservation strategies in post-pubertal cancer patients, including those with hereditary …

Serum detection of nonadherence to adjuvant tamoxifen and breast cancer recurrence risk

B Pistilli, A Paci, AR Ferreira, A Di Meglio… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Nonadherence to long-term treatments is often under-recognized by physicians
and there is no gold standard for its assessment. In breast cancer, nonadherence to …

Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting

B Buonomo, C Massarotti, M Dellino, P Anserini… - BMC medicine, 2021 - Springer
Background Healthy individuals and patients with cancer who are carriers of germline
pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that …

Fertility preservation using GnRH agonists: rationale, possible mechanisms, and explanation of controversy

Z Blumenfeld - Clinical Medicine Insights: Reproductive …, 2019 - journals.sagepub.com
The only clinically accepted method of fertility preservation in young women facing
gonadotoxic chemo-and/or radiotherapy for malignant or autoimmune diseases is …

Long-term outcomes with pharmacological ovarian suppression during chemotherapy in premenopausal early breast cancer patients

M Lambertini, L Boni, A Michelotti… - JNCI: Journal of the …, 2022 - academic.oup.com
Background Although use of gonadotropin-releasing hormone agonist (GnRHa) during
chemotherapy is an established strategy to protect ovarian function in premenopausal …

Implications of nonphysiological ovarian primordial follicle activation for fertility preservation

J Grosbois, M Devos, I Demeestere - Endocrine reviews, 2020 - academic.oup.com
In recent years, ovarian tissue cryopreservation has rapidly developed as a successful
method for preserving the fertility of girls and young women with cancer or benign conditions …

Advances in the treatment and prevention of chemotherapy-induced ovarian toxicity

HW Cho, S Lee, KJ Min, JH Hong, JY Song… - International Journal of …, 2020 - mdpi.com
Due to improvements in chemotherapeutic agents, cancer treatment efficacy and cancer
patient survival rates have greatly improved, but unfortunately gonadal damage remains a …

[HTML][HTML] Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach

M Salama, A Anazodo, TK Woodruff - Annals of Oncology, 2019 - Elsevier
Oncofertility is a new interdisciplinary field at the intersection of oncology and reproductive
medicine that expands fertility options for young cancer patients. The most common forms of …