ProNGF: a neurotrophic or an apoptotic molecule?
M Fahnestock, G Yu, MD Coughlin - Progress in brain research, 2004 - Elsevier
Nerve growth factor (NGF) acts on various classes of central and peripheral neurons to
promote cell survival, stimulate neurite outgrowth and modulate differentiation. NGF is …
promote cell survival, stimulate neurite outgrowth and modulate differentiation. NGF is …
A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and …
GA Dienel, A Schousboe, MC McKenna… - Journal of …, 2024 - Wiley Online Library
Abstract Leif Hertz, MD, D. Sc.(honōris causā)(1930–2018), was one of the original and
noteworthy participants in the International Conference on Brain Energy Metabolism …
noteworthy participants in the International Conference on Brain Energy Metabolism …
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions
M Imbernon, C Saponaro, HCC Helms, M Duquenne… - Cell metabolism, 2022 - cell.com
Liraglutide, an anti-diabetic drug and agonist of the glucagon-like peptide one receptor
(GLP1R), has recently been approved to treat obesity in individuals with or without type 2 …
(GLP1R), has recently been approved to treat obesity in individuals with or without type 2 …
Glutamate transport and metabolism in astrocytes
U Sonnewald, N Westergaard, A Schousboe - Glia, 1997 - Wiley Online Library
Glutamate uptake and metabolism was studied in cerebral cortical astrocytes. The
expression of the astrocytic glutamate transporter GLAST was found to be stimulated by …
expression of the astrocytic glutamate transporter GLAST was found to be stimulated by …
Direct demonstration by [13C] NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons
U Sonnewald, N Westergaard, A Schousboe… - Neurochemistry …, 1993 - Elsevier
Primary cultures of cerebral cortical astrocytes and neurons, as well as neurons growing on
top of the astrocytes (sandwich co-cultures), were incubated with 1-[13 C] glucose or 2-[13 …
top of the astrocytes (sandwich co-cultures), were incubated with 1-[13 C] glucose or 2-[13 …
Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes
P Kaur, M Aschner, T Syversen - Neurotoxicology, 2006 - Elsevier
Methyl mercury (MeHg) is highly neurotoxic and may lead to numerous neurodegenerative
disorders. In this study, we investigated the role of glutathione (GSH) and reactive oxygen …
disorders. In this study, we investigated the role of glutathione (GSH) and reactive oxygen …
Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia
G Gegelashvili, NC Danbolt… - Journal of …, 1997 - Wiley Online Library
The glutamate transporters in the plasma membranes of neural cells secure termination of
the glutamatergic synaptic transmission and keep the glutamate levels below toxic …
the glutamatergic synaptic transmission and keep the glutamate levels below toxic …
The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms
G Gegelashvili, Y Dehnes, NC Danbolt… - Neurochemistry …, 2000 - Elsevier
High-affinity glutamate transporters ensure termination of glutamatergic neurotransmission
and keep the synaptic concentration of this amino acid below excitotoxic levels. However …
and keep the synaptic concentration of this amino acid below excitotoxic levels. However …
FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier
I Bechmann, G Mor, J Nilsen, M Eliza, R Nitsch… - Glia, 1999 - Wiley Online Library
Despite the mechanical blood‐brain barrier, activated T‐cells can cross brain vessels. Thus,
the CNS is routinely surveyed by immune competent cells; yet the healthy brain is not a …
the CNS is routinely surveyed by immune competent cells; yet the healthy brain is not a …
Metabolism of [U‐13C]Glutamate in Astrocytes Studied by 13C NMR Spectroscopy: Incorporation of More Label into Lactate than into Glutamine Demonstrates the …
U Sonnewald, N Westergaard… - Journal of …, 1993 - Wiley Online Library
Primary cultures of cerebral cortical astrocytes were incubated with [U‐13C] glutamate (0.5
mM) in modified Dulbecco's medium for 2 h. Perchloric acid (PCA) extracts of the cells as …
mM) in modified Dulbecco's medium for 2 h. Perchloric acid (PCA) extracts of the cells as …