NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …
Altered iron metabolism and impact in cancer biology, metastasis, and immunology
Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …
Icariin‐induced inhibition of SIRT6/NF‐κB triggers redox mediated apoptosis and enhances anti‐tumor immunity in triple‐negative breast cancer
L Song, X Chen, L Mi, C Liu, S Zhu, T Yang… - Cancer …, 2020 - Wiley Online Library
Abnormal activation of the nuclear factor‐kappa B (NF‐κB) signaling pathway is closely
implicated in triple‐negative breast cancer growth, metastasis, and tumor immune escape. In …
implicated in triple‐negative breast cancer growth, metastasis, and tumor immune escape. In …
The oncogenic signaling disruptor, NDRG1: molecular and cellular mechanisms of activity
J Chekmarev, MG Azad, DR Richardson - Cells, 2021 - mdpi.com
NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers,
including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in …
including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in …
The role of the NDRG1 in the pathogenesis and treatment of breast cancer
X Zhao, DR Richardson - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …
NDRG1 in cancer: a suppressor, promoter, or both?
V Joshi, SR Lakhani, AE McCart Reed - Cancers, 2022 - mdpi.com
Simple Summary NDRG1 (N-myc downregulated gene-1) has been reported to suppress
metastasis, to be a biomarker of poor outcome, and to be a facilitator of disease progression …
metastasis, to be a biomarker of poor outcome, and to be a facilitator of disease progression …
The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer
N-myc-downregulated gene 1 (NDRG1) has potent anticancer effects and inhibits cell
growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is …
growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is …
Alterations of ion homeostasis in cancer metastasis: Implications for treatment
We have previously reported that metastases from all malignancies are characterized by a
core program of gene expression that suppresses extracellular matrix interactions, induces …
core program of gene expression that suppresses extracellular matrix interactions, induces …
Nanodiamonds inhibit cancer cell migration by strengthening cell adhesion: implications for cancer treatment
Nanodiamonds (NDs) are a type of biocompatible nanomaterial with easily modified
surfaces and are considered as promising candidates in biomedicine. In this work, the …
surfaces and are considered as promising candidates in biomedicine. In this work, the …
Metformin and histone deacetylase inhibitor based anti-inflammatory nanoplatform for epithelial-mesenchymal transition suppression and metastatic tumor treatment
T Jiang, L Xie, S Zhou, Y Liu, Y Huang, N Mei… - Journal of …, 2022 - Springer
Abstract Epithelial-mesenchymal transition (EMT), a differentiation process with aberrant
changes of tumor cells, is identified as an initial and vital procedure for metastatic processes …
changes of tumor cells, is identified as an initial and vital procedure for metastatic processes …