NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

S Mirzaei, S Saghari, F Bassiri, R Raesi… - Journal of cellular …, 2022 - Wiley Online Library
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

Altered iron metabolism and impact in cancer biology, metastasis, and immunology

RAM Brown, KL Richardson, TD Kabir, D Trinder… - Frontiers in …, 2020 - frontiersin.org
Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Icariin‐induced inhibition of SIRT6/NF‐κB triggers redox mediated apoptosis and enhances anti‐tumor immunity in triple‐negative breast cancer

L Song, X Chen, L Mi, C Liu, S Zhu, T Yang… - Cancer …, 2020 - Wiley Online Library
Abnormal activation of the nuclear factor‐kappa B (NF‐κB) signaling pathway is closely
implicated in triple‐negative breast cancer growth, metastasis, and tumor immune escape. In …

The oncogenic signaling disruptor, NDRG1: molecular and cellular mechanisms of activity

J Chekmarev, MG Azad, DR Richardson - Cells, 2021 - mdpi.com
NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers,
including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in …

The role of the NDRG1 in the pathogenesis and treatment of breast cancer

X Zhao, DR Richardson - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …

NDRG1 in cancer: a suppressor, promoter, or both?

V Joshi, SR Lakhani, AE McCart Reed - Cancers, 2022 - mdpi.com
Simple Summary NDRG1 (N-myc downregulated gene-1) has been reported to suppress
metastasis, to be a biomarker of poor outcome, and to be a facilitator of disease progression …

The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer

SC Lim, B Geleta, S Maleki, DR Richardson… - Journal of Biological …, 2021 - ASBMB
N-myc-downregulated gene 1 (NDRG1) has potent anticancer effects and inhibits cell
growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is …

Alterations of ion homeostasis in cancer metastasis: Implications for treatment

G Fnu, GF Weber - Frontiers in Oncology, 2021 - frontiersin.org
We have previously reported that metastases from all malignancies are characterized by a
core program of gene expression that suppresses extracellular matrix interactions, induces …

Nanodiamonds inhibit cancer cell migration by strengthening cell adhesion: implications for cancer treatment

Q Guo, L Li, G Gao, R Liu, Y Einaga… - ACS applied materials & …, 2021 - ACS Publications
Nanodiamonds (NDs) are a type of biocompatible nanomaterial with easily modified
surfaces and are considered as promising candidates in biomedicine. In this work, the …

Metformin and histone deacetylase inhibitor based anti-inflammatory nanoplatform for epithelial-mesenchymal transition suppression and metastatic tumor treatment

T Jiang, L Xie, S Zhou, Y Liu, Y Huang, N Mei… - Journal of …, 2022 - Springer
Abstract Epithelial-mesenchymal transition (EMT), a differentiation process with aberrant
changes of tumor cells, is identified as an initial and vital procedure for metastatic processes …